13C-labeled pyruvate is a clinically available key tracer for hyperpolarized 13C metabolic MRI study. An automated hyperpolarizing system of [1-13C]pyruvate using a low-cost parahydrogen induced polarization (PHIP) with side-arm hydrogenation (SAH), in which hyperpolarization is initially induced to the parahydrogen derived two 1Hs on unsaturated pyruvate precursor followed by the polarization transfer to a 13C of pyruvate, was developed. Magnetic field cycling process for 1H-to-13C polarization transfer process was optimized by the experimentally determined J-coupling network of pyruvate precursor and quantum chemical simulation, and its possible applications for cancer research are investigated in tumor-bearing mouse model.
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