Abstract #4266

18F-Fluoroethyltyrosine PET and Multiple Quantum Filtered Sodium MRI in Cerebral Gliomas

Wieland A. Worthoff¹, Aliaksandra Shymanskaya², Philipp Lohmann¹, Karl-Josef Langen^1,3,4, and N. Jon Shah^1,2,4,5

¹Institute of Neuroscience and Medicine - 4, Forschungszentrum Jülich GmbH, Jülich, Germany, ²Institute of Neuroscience and Medicine - 11, Forschungszentrum Jülich GmbH, Jülich, Germany, ³Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, ⁴Jülich-Aachen Research Alliance (JARA) - Section JARA-Brain, Aachen, Germany, ⁵Department of Neurology, RWTH Aachen University, Aachen, Germany

[¹⁸F]-FET-PET and sodium MRI were carried out on a cohort of patients with untreated cerebral gliomas. It is shown that the results from multiple quantum filtered sodium MRI using the enhanced SISTINA sequence are related to IDH mutational status in contrast to [¹⁸F]-FET-PET, thus providing the diagnostic potential to predict the genetic profile of gliomas.

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