Abstract #4263

Macrocyclic Manganese (II) Complex of Mefenamic acid (MA) Conjugate as an Inflammation Targeting MRI Contrast Agent

Md Kamrul Islam¹, Hee-Kyung Kim^2,3, Soyeon Kim¹, Bo Kyung Sung¹, Garam Choi¹, Ah Rum Baek¹, Sunghwan Hwang¹, Byeong Woo Yang¹, Heejin Seo¹, Hoesu Jung⁴, Taekwan Lee⁴, and Yongmin Chang⁵

¹Medical and Biological Engineering, Kyungpook National University, Daegu, Korea, Republic of, ²Molecular Medicine, Kyungpook National University, Daegu, Korea, Republic of, ³3Institute of Biomedical Engineering Research, Kyungpook National University, Daegu, Korea, Republic of, ⁴Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea, Republic of, ⁵Radiology, Kyungpook National University, Daegu, Korea, Republic of

The purpose of the present study is to design and synthesis of novel macrocyclic Mn²⁺ complex as an alternative to the well-established Gd³⁺ based chelates for use as an inflammation targeting MR imaging agent. This new complex exhibits higher r1 relaxivity (2.32 mM⁻¹ s⁻¹) than clinically approved Mn-DPDP® (1.6 mM⁻¹ s⁻¹) at 4.7 T. T₁-weighted MR coronal images display strong signal enhancement in liver, heart, gallbladder and kidney. In an inflammatory mouse model, it shows greater inflammatory tissues detection with in a clinical dose.

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