Abstract #4256

Toward in vivo quantification of microparticles of iron oxide targeting cerebrovascular inflammation

Jérémie P. Fouquet¹, Dina Sikpa¹, Renat Sibgatulin², Andreas Deistung², Martin Krämer², Luc Tremblay¹, Karl-Heinz Herrmann², Réjean Lebel¹, Jürgen R. Reichenbach², and Martin Lepage¹

¹Sherbrooke Molecular Imaging Center (CIMS), Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Sherbrooke, QC, Canada, ²Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany

Microparticles of iron oxide (MPIOs) can be detected by MRI with high sensitivity. This has recently led to their utilization as efficient contrast agents for molecular imaging or cell tracking. We present first steps toward in vivo quantification of a targeted MPIO that is widely used for inflammation imaging. These steps include 1) relaxivities and molar susceptibility measurements on a phantom, 2) in vivo estimation of the concentration of inflammation-specific MPIOs in a mouse model of cerebrovascular inflammation and 3) acquisition of ex vivo images that validate the results obtained in vivo.

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