Abstract #4251

Proton MRS and resting state fMRI study of hyperbaric oxygenation effects at 3 Tesla

Andrei Manzhurtsev^1,2, Natalia Semenova^1,2,3, Natalia Zaytseva⁴, Viktoria Sergeeva⁴, Petr Menshchikov^1,3, Maxim Ublinskiy^1,2, and Tolib Akhadov²

¹Emanuel Institute of Biochemical Physics of RAS, Moscow, Russian Federation, ²Radiology, Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russian Federation, ³Semenov Institute of Chemical Physics of the Russian Acedemy of Sciences, Moscow, Russian Federation, ⁴Clinical and Research Institute of Emergency Pediatric Surgery and Traumatology, Moscow, Russian Federation

Previously we demonstrated that one hyperbaric oxygenation (HBO) session causes the energy metabolism activation in order to compensate the expenses on NAD(H) synthesis. This study is aimed to reveal the effects of HBO on the ¹H MRS brain metabolites and the correlated activity in DMN at 3 Tesla. The results demonstrate that even one low-pressure HBO session in healthy subjects stimulates NAA brain metabolism and increases the MPFC-PCC functional connectivity. Further research of HBO effects on neuronal pathology subjects is of interest.

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