In vivo magnetic resonance spectroscopy currently lacks data-driven quality control standards, the development of which can be informed by characterizing the effects of spectral quality on metabolite quantification. We assess the influences of spectral line width and signal-to-noise ratio on both simulated and experimentally derived in vivo resonances from twenty-one metabolites measured by short-echo-time STEAM and J-difference editing for glutathione and GABA at 7 Tesla. We show that spectral quality exerts distinct effects on apparent concentrations of different metabolites, underlining the importance of explicit quality analysis in studies employing in vivo magnetic resonance spectroscopy, especially cross-sectional investigations of physiologically distinct groups.
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