Abstract #4235

T2 Measurement and quantification of cerebral white and gray matter aspartate concentrations in vivo

Petr Menshchikov^1,2, Andrei Manzhurtsev^2,3, Maxim Ublinskii ², Tolib Akhadov², and Natalia Semenova^1,2,3

¹Semenov Institute of Chemical Physics of RAS, Moscow, Russian Federation, ²Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, ³Emanuele Institute of Biochemical Physics of RAS, Moscow, Russian Federation

In this study for the first time in vivo transverse relaxation rate (T₂) of aspartate (Asp) from Asp edited MEGA-PRESS spectra using phanton data were quantified as 161±33 ms. Asp concentrations in gray matter (GM)- and white matter (WM)-dominant brain regions were measured as 2.78±0.21 mM vs 1.04±0.16 mM, respectively. Estimation of the absolute Asp concentrations with Asp editing MEGA-PRESS has potential in many research applications, such as studying the processes underlying the reduction of N‐acetyl aspartate. The T₂ measurement method which has been successfully applied for edited Asp signals can also be used for other strongly J-coupled signals.

This abstract and the presentation materials are available to members only; a login is required.

Join Here