Abstract #4225

Glucose metabolism in the brain of an Alzheimer mouse model by deuterium MRS

Andor Veltien¹, Jack Van Asten¹, Tom Peeters¹, Maximilian Wiesmann², Ria De Haas³, Amanda Kiliaan², and Arend Heerschap¹

¹Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, ²Department of Anatomy, Radboud university medical center, Nijmegen, Netherlands, ³Department of Pediatrics of Radboud Center for Mitochondrial Medicine, Radboud university medical center, Nijmegen, Netherlands

In this study we show that Deuterium Magnetic Resonance Spectroscopy (DMRS) of the mouse brain after a bolus application of [6,6’-²H₂]glucose is feasible at a high SNR and time resolution. We demonstrate that this can be applied to a transgenic mouse model of Alzheimer disease showing clear differences in the glucose uptake and metabolism with a WT mouse. In Deuterium Metabolic Imaging (DMI) mode this could be an alternative approach for FDG PET in Alzheimer disease.

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