Abstract #4209

Fluorine-19 Magnetic Resonance Thermometry: Temperature Dependence of Spin-Lattice and Spin-Spin-Relaxation Times of Fluorinated Drugs at 9.4 T

Christian Prinz¹, Paula Ramos Delgado¹, Thomas Wilhelm Eigentler¹, Ludger Starke¹, Thoralf Niendorf^1,2, and Sonia Waiczies¹

¹Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine, Berlin, Germany, ²Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany

Fluorine-19 (¹⁹F) magnetic resonance is a powerful tool for tracking fluorine labelled markers, cells and drugs. Here, we studied the influence of temperature on the ¹⁹F MR characteristics (chemical shift, T₁, T₂, SNR) of four fluorinated drugs using ¹⁹F MR mapping and spectroscopy techniques. We demonstrated the impact of temperature on the T₁ relaxation time of PFCE nanoparticles in vivo and postmortem. Our findings open a trajectory toward ¹⁹F MR-based thermometry and indicate the need for adapting MR sequence parameters according to temperature induced environmental changes. This will be an essential requirement for monitoring fluorinated compounds by ¹⁹F MR techniques in vivo.

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