Abstract #4150

Multi-center Comparison of Image Quality Using a Thermally Polarized 129Xe Phantom

Elianna Bier^1,2, John Nouls², Ziyi Wang^1,2, Mu He^2,3, Ralph Hashoian⁴, John Mugler⁵, and Bastiaan Driehuys^1,2,6

¹Biomedical Engineering, Duke University, Durham, NC, United States, ²Center for In Vivo Microscopy, Duke University, Durham, NC, United States, ³Electrical and Computer Engineering, Duke University, Durham, NC, United States, ⁴Clinical MR Solutions, Brookfield, WI, United States, ⁵Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, United States, ⁶Radiology, Duke University Medical Center, Durham, NC, United States

Multiple centers are starting to use hyperpolarized ¹²⁹Xe MR imaging and spectroscopy to quantify pulmonary function. This drives the need for standardization and quality assurance (QA), which is challenging for short-lived hyperpolarized agents. To address this, we developed a high pressure thermal ¹²⁹Xe phantom constructed from high-density polyethylene and an associated loader shell that mimics the human torso. The phantom was imaged at 8 institutions across North America comprising a variety of scanners, vendors, coils, and field strengths. Image SNR measured with a minute-long scan agreed within a factor of 2 across sites and enabled rapid comparison of MR configurations.

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