Abstract #4077

Functional and Developmental Effects of Zika Virus Infection and Hydroxychloroquine Treatment in Mouse Placenta

Kelsey V Meinerz¹, Brooke Liang², James D Quirk³, Indira U Mysorekar^2,4, and Joel R Garbow^3,5

¹Physics, Washington University in St Louis, Saint Louis, MO, United States, ²Obstetrics and Gynecology, Washington University in St Louis, Saint Louis, MO, United States, ³Mallinckrodt Institute of Radiology, Washington University in St Louis, Saint Louis, MO, United States, ⁴Center for Reproductive Health Sciences, Washington University in St Louis, Saint Louis, MO, United States, ⁵Siteman Cancer Center, Washington University in St Louis, Saint Louis, MO, United States

Functional and developmental effects of Zika virus (ZIKV) infection and hydroxychloroquine (HCQ) treatment on the murine placenta were measured using MRI and oxygen enhancement to assess placental volume and oxygenation. HCQ treatment helps to prevent adverse placental volume outcomes earlier in gestation, but late-gestation results are similar to those of ZIKV-infected dams. R₁ and R₂^* measurements show that HCQ has a significant effect on placental oxygenation throughout gestation, whereas ZIKV does not significantly affect these metrics.

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