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Abstract #4073

Reliable assessment of apparent diffusion coefficient in normal and ventriculomegaly fetal brains

Maria Giovanna Di Trani1,2, Lucia Manganaro3, Amanda Antonelli3, Michele Guerreri2, Riccardo De Feo1, Mattia Borrelli4, Giacomo Pratesi4, Carlo Catalano3, and Silvia Capuani5

1Centro Fermi - Museo storico della Fisica e centro studi e ricerche Enrico Fermi, Rome, Italy, 2SAIMLAL, Sapienza University of Rome, Rome, Italy, 3Radiological Sciences, Sapienza University of Rome, Rome, Italy, 4Physics, Sapienza University of Rome, Rome, Italy, 5Physics, CNR-Institute for Complex Systems, Rome, Italy

Ventriculomegaly (VM) is one of the most common disease in fetuses; however, DWI studies during gestation are scarce. In this work, DWI was performed in normal and VM fetal brains at different gestational ages (GA) and ADC was calculated. Denoising and artifacts corrections were used to improve signal-to-noise ratio and the reliability of measures. We found significant variations in ADC as GA increases, reflecting microstructural changes due to brain maturation. Moreover, ventricles dilatation measured on DWIs provided an accurate classification of VM. DWI with artifacts corrections could be a powerful tool to evaluate brain abnormalities and accurately diagnose VM.

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Abstract