Abstract #4036

Evaluating effect of Combination and Number of Multiple b-values in IVIM Analysis of Prostate

Archana Vadiraj Malagi¹, Chandan J. Das², Kedar Khare³, Fernando Calamante⁴, and Amit Mehndiratta^1,5

¹Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, ²Department of Radiology, All India Institute of Medical Sciences Delhi, New Delhi, India, ³Department of Physics, Indian Institute of Technology Delhi, New Delhi, India, ⁴Sydney Imaging and School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Sydney, Australia, ⁵Department of Biomedical Engineering, All India Institute of Medical Sciences Delhi, New Delhi, India

Optimization of b-values in DWI-IVIM is necessary for precision and reproducibility of parameter estimation. The IVIM biexponential model with Total variation correction (BE+TV) method was used here, which reduces sudden changes in parameter values and removes non-physiological heterogeneity in maps. Various b-value combinations were utilized in prostate: 4, 8 and 13 b-values. 8 and 13 b-values showed similar trend in coefficient of variation (CV), which was confirmed using Bland-Altman plots, including comparable qualitative maps; in contrast, 4 b-values showed variable CV and noisy maps. In prostate, 8 b-values can be used with Total Variation method for faster acquisition protocol and low variability in parameter maps.

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