We compared monoexponential and non-Gaussian models including intravoxel incoherent motion imaging (IVIM) and stretched-exponential model in diffusion-weighted imaging (DWI) for characterization of prostate cancer. ADCmean in monoexponential model, D in IVIM, and DDC in stretched model showed high discrimination ability with AUC>0.80 between GS=3+3 and GS≥3+4 tumors as well as GS≤3 + 4 and GS≥4 + 3 tumors, but no significant difference among these metrics. Our study did not show a clear clinical value of non-Gaussian models including IVIM and stretched model compared with standard monoexponential model for assessment of tumor aggressiveness in prostate cancer.
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