Abstract #3997

Pulsed Saturation Transfer in Glioblastoma at 1.5T

Rachel W. Chan¹, Sten Myrehaug^2,3, Greg J. Stanisz^1,4,5, Arjun Sahgal^1,2,3, and Angus Z. Lau^1,4

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada, ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁵Department of Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin, Poland

The purpose of this study was to quantify the effects of saturation transfer (CEST and MT) measurements in glioblastoma (GBM) patients at 1.5T. Data from GBM patients (n=10), treated with intensity modulated radiation therapy with a dose of 2 Gy per session with concurrent temozolomide, were analyzed before and after 10 treatment fractions. MT data were fitted to the Bloch-McConnell (BM) equations using a two-pool model with extended phase graphs (EPG) incorporated into the model. Results showed differences between normal and tumor regions and demonstrated promise for the application of CEST at 1.5T.

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