Abstract #3991

Thermal sensitive pH imaging using CEST

Yuki Kanazawa¹, Daiki Chiba¹, Masafumi Harada¹, Tosiaki Miyati², Mitsuharu Miyoshi³, Hiroaki Hayashi², Yuki Matsumoto¹, Takashi Abe¹, and Akihiro Haga¹

¹Tokushima University, Tokushima, Japan, ²Kanazawa University, Kanazawa, Japan, ³Global MR Applications and Workflow, GE Healthcare Japan, Tokyo, Japan

We performed phantom study with CEST and clarified pH change depending on temperature. Linear regression analysis shows a strong significant correlation between temperature and MTR_asym at 2.0 ppm in all egg white albumin samples (R² > 0.78, P < 0.05). As pH changed with temperature, we found that the offset frequency of MTR_asym was more sensitive at 2.0 ppm than that at 3.5 ppm.

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