Healthy aging affects the local mechanical properties of the human brain tissue but their estimation remains a challenge, especially in strongly anisotropic white matter regions. This study merges previous MRE aging research involving high-resolution, full-coverage, and multi-excitation MRE imaging with the ability to estimate anisotropic shear moduli locally. We identified important anisotropic differences in the storage modulus in the corpus callosum, which help differentiate old from the young.
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