Abstract #3946

Comparison of continuous sampling with active noise cancellation and sparse sampling for cortical and subcortical auditory fMRI

Rebecca Susan Dewey^1,2,3, Deborah A Hall^2,3,4, Christopher J Plack^5,6,7, and Susan T Francis¹

¹Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom, ³Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁴University of Nottingham Malaysia, Jalan Broga, Selangor Darul Ehsan, Malaysia, ⁵Manchester Centre for Audiology and Deafness (ManCAD), University of Manchester, Manchester, United Kingdom, ⁶NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom, ⁷Department of Psychology, Lancaster University, Lancaster, United Kingdom

We compared cortical and subcortical auditory BOLD fMRI responses to epochs of broadband noise acquired using continuous sampling with active noise cancellation (TR = 2s) to sparse sampling (TR = 8s, 1993ms acquisition with 6007ms silence) in a repeated measures factorial design. High resolution (1.5 mm³) 3 Tesla fMRI data were acquired using multiband 2 and corrected for physiological noise and image distortions. BOLD beta estimates are compared for onset, offset and sustained auditory fMRI responses for both sampling schemes. We report the strengths and weaknesses of the two sampling methods.

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