Abstract #3904

Default mode networks connectivity characterization in young adults with sickle cell disease using 7T resting functional magnetic resonance imaging

Nadim S Farhat¹, Helmet T Karim², Tales Santini¹, Neilesh Vinjamuri¹, Howard J Aizenstein^1,2, Enrico M Novelli^3,4,5, and Tamer S Ibrahim^1,6,7

¹Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ²Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, United States, ³Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh school of medicine, Pittsburgh, PA, United States, ⁴Sickle Cell Center of Excellence, University of Pittsburgh school of medicine, Pittsburgh, PA, United States, ⁵Division of Hematology/Oncology, University of Pittsburgh school of medicine, Pittsburgh, PA, United States, ⁶Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States, ⁷Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States

In this study, we investigated altered resting state default mode network (DMN) connectivity using functional magnetic resonance imaging (rs-fMRI) at 7T in young adults(n=13) with sickle cell disease. The DMN of SCD of young adults had higher connectivity as compared to a healthy controls(n=9 ) gender, age, and racially matched group.

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