Abstract #3878

Regional Brain Resting-State Neural Activity in Patients with Single Ventricle Heart Disease

Xiaopeng Song¹, Bhaswati Roy², Sadhana Singh¹, Ashish Kaul Sahib¹, Nancy Halnon³, Alan Lewis⁴, Mary Woo², Nancy Pike⁵, and Rajesh Kumar¹

¹Departments of Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States, ²School of nursing, University of California Los Angeles, Los Angeles, CA, United States, ³Division of Pediatric Cardiology, University of California Los Angeles, Los Angeles, CA, United States, ⁴Division of Pediatric Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁵University of California Los Angeles, Los Angeles, CA, United States

Patients with single ventricle heart disease (SVHD) commonly show brain structural injuries in autonomic, mood, and cognition regulatory areas. However, whether SVHD subjects have functional impairments in these sites is unknown. We examined regional neural activity changes in SVHD patients, and found reduced regional homogeneity (ReHo) in posterior cingulate, medial prefrontal cortex, inferior parietal lobule, and left insula, and increased ReHo in bilateral middle occipital gyrus, cerebellar cortices, and left superior temporal gyrus over control subjects. These functional changes might be associated with impairments in autonomic, mood, and cognitive functions found in the condition.

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