Abstract #3860

Multi-Slice LINE-scanning (MS-LINE) method to characterize the laminar specificity and variability in both evoked and resting-state fMRI

Sangcheon Choi^1,2, Hang Zeng^1,2, Bharat Biswal³, Bruce R. Rosen⁴, and Xin Yu^1,4

¹Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Graduate Training Centre of Neuroscience, Tuebingen, Germany, ³Department of Biomedical Engineering, NIJT, Newark, NJ, United States, ⁴MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States

Ultra-high field magnetic field strengths open new possibility for studying the neuronal input/output circuitry of the cortex and functional connectivity across the cortical layers. However, the spatiotemporal characteristics of laminar-specific fMRI signal remains to be better characterized in both task-related and resting state condition. Here, we present Multi-Slice FLASH based LINE-scanning (MS-LINE) methods, showing the multi-slice laminar-specific fMRI variability at different cortical regions of anesthetized rats. The results identify the distinct neurovascular coupling laminar patterns corresponding to different state of brain activity.

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