Abstract #3810

Enhancement of the HIFU thermal effect in ex-vivo kidneys using a new class of endovascular sono-sensitizers

Orane Lorton¹, Pauline Guillemin¹, Romain Breguet², Stéphane Desgranges³, Laura Gui¹, François Lazeyras⁴, Antonio Nastasi⁵, Lindsey A. Crowe², Nicolas Taulier⁶, Christiane Contino-Pépin³, and Rares Salomir^1,2

¹Image Guided Interventions Laboratory, Faculty of Medicine, University of Geneva, Geneva, Switzerland, Geneva, Switzerland, ²Radiology Department, University Hospitals of Geneva, Geneva, Switzerland, Geneva, Switzerland, ³University of Avignon, CBSA-IBMM (UMR5247), Avignon, France, Avignon, Switzerland, ⁴Department of Radiology and Medical Informatics, University of Geneva, Switzerland, Geneva, Switzerland, ⁵Research and Development Laboratory, Visceral and Transplantation Service, University Hospital Geneva, Geneva, Switzerland., Geneva, Switzerland, ⁶Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Laboratoire d’Imagerie Biomédicale (LIB), F-75006, Paris, France, Paris, Switzerland

Magnetic Resonance guided High Intensity Focused Ultrasound (MRgHIFU) is a promising approach for the non-invasive ablation of localized tumors. Ablation of highly perfused tumors is challenging due to the heat sink effect. We developed a new concept of endovascular liquid core micro-droplets, used as sono-sensitizers for the enhanced absorption of the HIFU beam. We demonstrated the improvement of the HIFU thermal effect after adjunction of sono-activable micro-droplets in the perfusion fluid of freshly excised viable pig kidneys. Temperature maps were computed using the PRFS method to prove the enhancement of thermal contrast.

This abstract and the presentation materials are available to members only; a login is required.

Join Here