Inhalants are legal, inexpensive substances that are often abused by adolescents. This study compared the BOLD changes in brain associated with cue-induced craving in adolescent inhalant users (n=13) and healthy controls (n=12) to elucidate the neural mechanisms associated with cue-induced craving. The cases exhibited an increased activation of superior occipital gyrus, inferior parietal lobule, cingulate gyrus, thalamus, and culmen and a decreased activation of insula as compared to control group for craving cues. Visual cue reactivity was associated with activation of the areas responsible for visual perception, visuo-spatial attention and working memory, control and motivation.
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