Optogenetically-evoked spindle-like activity from thalamus propagates brain-wide and enhances rsfMRI connectivity
Xunda Wang1,2, Alex T. L. Leong1,2, Shuai Guo1,2, Celia M. Dong1,2, and Ed X. Wu1,2
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China
Hierarchical nesting of spindles and slow oscillations have been identified as a unique characteristic for long-range functional neural integrations in thalamo-cortical network. Meanwhile, low spontaneous oscillatory neural activities are proposed to constrain and elicit resting state fMRI connectivity. Yet, the brain-wide spindle-related BOLD activity and the contribution of thalamic spindle-like activity to brain-wide rsfMRI connectivity remain largely unknown. We demonstrate for the first time that the spindle-like optogenetic stimulation at the somatosensory thalamus can evoke robust BOLD activations brain-wide and influence brain-wide rsfMRI connectivity. Our work suggests that interaction between spindles and slow oscillations is important for maintain rsfMRI connectivity.
This abstract and the presentation materials are available to members only;
a login is required.
