Thalamus has the capacity to generate oscillations characterized by different frequency and levels of synchrony. However, little is known of what function the generated EEG dynamic pattern may serve in thalamocortical interactions. In this study, we used psychophysiological interaction framework to detect fMRI thalamocortical coupling modulated by dynamic EEG connectivity patterns, and tested the alteration of the modulatory couplings in juvenile myoclonic epilepsy. The results found frequency-dependent characteristics for the thalamocortical coupling. The group comparison revealed the couplings were altered with certain thalamus sets involved in JME, which may have implications for better understanding of the thalamocortical circuit influenced by epileptic activity.
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