Abstract #3699

Effects of Isoflurane on Brain Functional Connectivity in Common Marmosets

Naoki Kawaguchi^1,2, Junichi Hata³, Yawara Haga^3,4, Kanako Muta⁵, Koya Yachida^1,3, Koshiro Terawaki^1,2, Hirotaka James Okano², Hideyuki Okano³, and Akira Furukawa⁴

¹Department of Radiological Sciences, Faculty of Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, ²Regenerative medicine, The Jikei University School of Medicine, Tokyo, Japan, ³Laboratory for Marmoset Neural Architecture, Center for Brain Science, RIKEN, Wako, Japan, ⁴Department of Radiological Sciences, Human Health Sciences, Tokyo Metropolitan University Graduate School, Tokyo, Japan, ⁵Veterinary Surgery Laboratory, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

We examined the effects of isoflurane on brain functional connectivity in common marmosets using resting-state fMRI. We found that the thalamus was closely related to the mechanism of action of anesthesia and the default mode network (DMN), which is thought to function at rest. Isoflurane exhibited similar effect on the thalamus and human DMN region in humans but partly different effect onthe marmoset DMN region.In the future, we need to perform further investigations in detail by increasing the amount of data and reviewing analysis methods.

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