Abstract #3655

Validation of Diffusion Imaging Measures in Gray Matter using Histology from macaque monkey

Madhura Baxi^1,2, Suheyla Cetin Karayumak², Doug Richardson³, George Papadimitriou⁴, Sarina Karmacharya², Nikos Makris², Andre van der Kouwe⁵, Bruce Jenkins⁵, Thomas Witzel⁵, Tara Moore⁶, Douglas Rosene⁶, Marek Kubicki², and Yogesh Rathi²

¹Graduate Program for Neuroscience, Boston University, Boston, MA, United States, ²Psychiatry NeuroImaging Lab, HMS, BWH, Boston, MA, United States, ³Harvard Center for Biological Imaging, Harvard University, Cambridge, MA, United States, ⁴Center for Morphometric Analysis, Massachusetts General Hospital, Charlestown, MA, United States, ⁵Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁶Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, United States

This study is the first attempt towards histological validation of diffusion imaging measure of Trace in the gray matter of macaque monkey. Heterogeneity of Trace (hTrace) computed for one monkey in 7 cytoarchitectonically different regions was compared with the variance in intracellular volume fraction for the same regions computed using digitized histological sections, stained for all cell bodies. hTrace was found to be significantly correlated with the variance in intracellular volume fraction. This shows that the diffusion measure of hTrace is sensitive to the underlying gray matter cytoarchitecture such as the cell size and cell packing density.

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