Abstract #3608

Diffusion Kurtosis Image in assessment of 3D Cell Culture

Jui-Heng Lin¹, Huei-Chun Hsiao¹, Shao-Chieh Lin¹, Yi-Jui Liu², Ruey-Hwang Chou³, Ke-Sin Yan³, Tan-Wei Liao³, Chao-Chun Lin⁴, Chia-Wei Lin⁴, and Wu-Chung Shen⁴

¹Master's Program of Biomedical Informatics and Biomedical Engineering, Feng Chia University, Taichung, Taiwan, ²Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, ³Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan, ⁴Department of Radiology, China Medical University Hospital, Taichung, Taiwan

A non-Gaussian kurtosis model has been shown to take into account tissue heterogeneity and two relative imaging biomarkers namely, the kurtosis coefficient and the corrected diffusion coefficient can be quantified. In this study, 3D cell culture with hydrogels ECM was used to investigate whether DKI may provide information on these microenvironmental parameters and the microenvironment-associated metastatic propensity of tumors. Our results demonstrated DKI-MRI may provide the potential biomarkers on the change of microenvironment in the application of 3D cell culture experiment.

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