Axonal degeneration is a hallmark of many neuropathologies, with a defined time course presenting distinct histological features. In single fiber regions, the tensor model provides reliable information in early and chronic phases of axonal damage. However, said model cannot accurately determine per-bundle characteristics in voxels occupied by axonal populations with different orientations. We evaluated two multiple-fiber methods in an animal model of axonal degeneration (unilateral retinal ischemia) to provide information about the sensitivity of these models related to microstructural changes occuring in the acute and early chronic stages of pathology in a crossing fiber region.
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