Most existing biophysical models used to quantify diffusion microstructural information are designed for the healthy brain. When pathological processes occur, the diffusion signal of cancerous regions is altered, possibly biasing the fitting results of these models and making their parameter estimates unreliable. In this work, we investigate the precision and accuracy of estimates provided by several well known diffusion models, by evaluating their goodness-of-fit with residual sum of squares map and the parameter reliability with the bootstrap technique.
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