1Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine IDP, University of California, Los Angeles, Los Angeles, CA, United States, 3Biomedical Engineering, Tsinghua University, Beijing, China, 4Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States
A 3D diffusion-prepared magnitude-stabilized bSSFP (DP-MS-bSSFP) sequence was proposed and validated to achieve high resolution distortion-free brain diffusion imaging. Shot-to-shot phase variation was corrected using the plane-by-plane MUSE technique. High-quality 3D diffusion images, ADC maps and cFA maps were obtained from four volunteers. Good agreement of white matter ADC between DW-ssEPI and DP-MS-bSSFP was observed based on the Bland-Altman plot. Geometric accuracy of DP-MS-bSSFP was confirmed by a four-fold reduction of target registration error compared with DW-ssEPI. In conclusion, the proposed DP-MS-bSSFP approach provided high-quality 3D diffusion images and diffusion tensor images with high ADC accuracy and minimal distortion.
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