Multidimensional diffusion encoding isotropic b-tensors eliminate rotational variance from anisotropic Gaussian diffusion, an essential feature for estimating microscopic anisotropy. In anisotropic substrates which exhibit non-Gaussian diffusion on the time scale of the encoding pulse, the variance in temporal characteristics of diffusion encoding across different directions – spectral anisotropy (SA) - may introduce a directional variance in apparent diffusivities. We propose an alternative isotropic encoding with drastically lower SA, which in turn allows accessing intrinsic signatures of non-Gaussian diffusion.
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