In vivo evaluation of biomaterial implant remodeling involves surgical removal of the implant for subsequent histological assessment, which is often destructive and limits the effective evaluation of these materials. Diffusion-weighted MRI has the potential to non-invasively monitor the remodeling of collagen scaffolds. This study investigated the role of apparent diffusion coefficient (ADC) from different diffusion regimes to evaluate the remodeling of implanted collagen scaffolds and correlated the findings to conventional histological techniques. Correlations between ADC and histological parameters demonstrated that MRI is sensitive to specific remodeling parameters which can aid in the design of robust biomaterial scaffolds for tissue regeneration.
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