Within the glymphatic system, CSF is transported in a network of perivascular channels where it exchanges with ISF to drive drainage of unwanted solutes, like amyloid- β, out of the brain. Perivascular channel impairment may be an early biomarker of neurodegenerative processes. Here, we present a pilot study for 3D non-invasive assessment of glymphatic function in the rat brain using ultra-long echo time diffusion MRI. We show that this technique is sensitive to the fluid movement in downstream perivascular channels that drives glymphatic inflow.
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