We describe an acquisition and reconstruction methodology that enables in vivo human diffusion tensor imaging with whole-brain coverage and 860$$$\mu$$$m isotropic spatial resolution, all within a 10 minute acquisition window on a commercial 3T scanner. Our approach is enabled by combining the gSlider-SMS acquisition approach (which uses simultaneous multi-slab acquisition for increased spatial coverage, combined with highly-efficient RF slab-encoding to achieve high spatial resolution) with an SNR-enhancing joint reconstruction approach that mitigates the noise associated with high-resolution acquisition.
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