Abstract #3336

Characterisation of ageing effects using multiparametric quantitative imaging

Ana-Maria Oros-Peusquens^1,2, Melissa Schall^1,2, Elene Iordanishvili¹, and N. Jon Shah^1,3,4,5

¹Institute of Neuroscience and Medicine - 4, INM-4, Forschungszentrum Jülich, Jülich, Germany, ²Authors with equal contributions, Jülich, Germany, ³Institute of Neuroscience and Medicine - 11, INM-11, Forschungszentrum Jülich, Jülich, Germany, ⁴Jara - BRAIN -Translational Medicine, Aachen, Germany, ⁵Department of Neurology, RWTH Aachen University, Aachen, Germany

A multiparametric, quantitative method was implemented in a population-based study of normal ageing - the 1000Brains study. Several parameters are derived with whole-brain, high-resolution imaging in TA=21min: these included water content, T1 and T2* relaxation times, their changes in the presence of saturation and calculated qMT parameters - MTR, bound proton fraction fboundand forward magnetization exchange rate (k_ex). Methodological precision is high allowing for detecting of ageing effects as illustrated by several parameters (T1, T2*, H2O, f_bound) from data sets of 25 healthy subjects (mean age 53±16 years, from 27 to 80, 18 male).

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