Abstract #3327

Quantitative pharmacokinetic comparison of adenoma and normal pituitary gland using high-temporal and spatial resolution dynamic contrast enhanced MRI

Kiyohisa Kamimura¹, Masanori Nakajo¹, Tomohide Yoneyama¹, Yoshihiko Fukukura¹, Shingo Fujio², Takashi Iwanaga³, Hiroshi Imai⁴, and Takashi Yoshiura¹

¹Radiology, Kagoshima University, Kagoshima, Japan, ²Neurosurgery, Kagoshima University, Kagoshima, Japan, ³Radiological Technology, Kagoshima University Hospital, Kagoshima, Japan, ⁴Siemens Healthcare K.K, Tokyo, Japan

Preoperative localization of the normal pituitary gland is important in patients with pituitary adenoma. Our aim was to evaluate the possible role of high-temporal and spatial resolution dynamic contrast enhanced MR imaging (DCE-MRI) and quantitative pharmacokinetic analysis in differentiation of the normal pituitary gland from pituitary adenoma. The normal pituitary gland showed significantly higher IAUC, K^trans, k_ep and v_e than pituitary adenoma. The ROC curve analysis showed significance for IAUC, K^trans, k_ep and v_e (AUC = 0.958, 0.882, 0.781 and 0.851, respectively). These quantitative parameters may be useful for differentiation of the normal pituitary gland from pituitary adenoma.

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