This longitudinal study investigates possible recovery of volumetric brain changes in pre-menopausal patients three years after being treated for early-stage breast cancer. While initial widespread white matter volume increase was previously observed, recovery is seen three years after treatment in the same group of young women treated with chemotherapy. Patients with breast cancer show widespread gray matter volume decrease, observed both in patients treated and not treated with cytotoxic agents. Further studies are necessary to unravel possible acute volumetric changes, possibly neuro-inflammatory mechanisms, in this population as a cause for these findings.
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