Abstract #3260

Vessel-specific Quantification of Neonatal Cerebral Venous Oxygenation

Dengrong Jiang¹, Hanzhang Lu², Charlamaine Parkinson³, Pan Su², Zhiliang Wei², Li Pan⁴, Aylin Tekes², Thierry A.G.M. Huisman², W. Christopher Golden³, and Peiying Liu²

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Siemens Healthineers, Baltimore, MD, United States

Cerebral metabolic rate of oxygen (CMRO₂) is an important biomarker for normal and pathological neonatal brain development. However, regional measurement of neonatal CMRO₂ has been limited due to an inability to evaluate regional venous blood oxygenation (Y_v). This study presented a rapid MRI technique, accelerated T₂-relaxation-under-phase-contrast (aTRUPC), to measure vessel-specific Y_v in neonates. We have improved the reliability and accuracy of aTRUPC by optimizing imaging parameters and calibrating T₂-bias. A pilot study on healthy, non-sedated neonates demonstrated the feasibility of aTRUPC to measure vessel-specific Y_v. Accuracy of aTRUPC-based Y_v measurements was further validated with established whole-brain Y_v measurement using T₂-relaxation-under-spin-tagging.

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