Abstract #3252

Interactive Correlation between Iron Deposition and Cerebral Blood Flow in the Deep Cerebral Gray Matter Structures of Hemodialysis Patients

Chao Chai¹, Huiying Wang¹, Jinping Li², Jinxia Zhu³, Xianchang Zhang³, E. Mark Haacke⁴, Shuang Xia¹, and Wen Shen¹

¹Department of Radiology, Tianjin First Central Hospital, Tianjin, China, ²Deparment of Hemodialysis, Tianjin First Central Hospital, Tianjin, China, ³MR Collaboration, Siemens Healthcare Ltd., Beijing, China, ⁴Department of Radiology, Wayne State University, Detroit, MI, United States

The aim of this study was to explore the correlation between iron deposition (ID) and cerebral blood flow (CBF) in the deep gray matter structures of hemodialysis patients using susceptibility-weighted image mapping and arterial spin labeling. Both ID and CBF of the patients were increased compared with the healthy controls. ID in patients was positively correlated with CBF in the right putamen, while negatively correlated with CBF in the right thalamus. Abnormal calcium-phosphorus metabolism and triglyceride were shared independent factors for increased ID and CBF. Increased ID, rather than CBF, was a risk factor for neurocognitive impairment.

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