Tissue
infarct due to major vessel occlusion depends on the compromised blood flow and
the time since onset. Compromised blood flow may be sustained by recruitment of
pial collateral vessels. In this study, the extent of pial collateral
recruitment was used to predict infarct volume in an experimental middle
cerebral artery occlusion animal model with and without norepinephrine and
hydralazine. An automatic method of infarct volume measurement was developed to
minimize user variability and time. The automatically calculated infarct
volumes were highly correlated to manually measured volumes, and pial
collaterals were predictive of infarct volume.
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