This work evaluated the prognostic potential for quantitative MRI measures of the spinal cord compared to neurological assessments in a rat model of spinal cord injury. The results demonstrate in the acute setting, that a double diffusion encoded spectroscopy acquisition has greater accuracy than either DWI-EPI or T2 mapping while in the chronic setting, measures of spinal cord atrophy perform better than DWI measures. These results set the basis for future patient studies to improve MRI biomarkers in spinal cord injury.
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