Abstract #3229

Neurochemical and structural early changes and onset time in 5xFAD model: MRS and VBM studies

Jang Woo Park¹, In OK Ko², Kyung Jung Kang², and Ji Ae Park²

¹Korea Drug Development Platform using Radio-isotope, Korea Institute of Radiological & Medical Sciences, Seoul, Korea, Republic of, ²Division of Applied RI, Korea Institute of Radiological & Medical Sciences, Seoul, Korea, Republic of

We investigated early neurochemical and structural changes in 5xFAD model using magnetic resonance spectroscopy (MRS) and Voxel-based morphometry (VBM). At 6 months, it was confirmed that Glu, NAA, Tau and volume, which is characteristic of Alzheimer’s disease (AD) model, decreased in hippocampus of 5xFAD model.

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