Abstract #3226

Neuroimaging of Nipah Virus infection in an African Green Monkey Model

Ji Hyun Lee¹, Yu Cong¹, Joseph Laux¹, Marcelo Castro¹, Matthew Lackemeyer¹, Jordan Bohannon¹, Oscar Rojas¹, Jeffery M. Solomon², Irwin M. Feuerstein¹, Vincent Munster³, Dima A. Hammoud⁴, and Michael R. Holbrook¹

¹IRF, NIAID/NIH, Frederick, MD, United States, ²Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, NCI Campus, Frederick, MD, United States, ³Virus Ecology Unit, Laboratory of Virology, Rocky, Mountain Laboratories, NIAID/NIH, Hamilton, MT, United States, ⁴Clinical Center, NIH, Bethesda, MD, United States

The purpose of this study was to utilize MRI to assess alterations in the brain that occur in African Green Monkeys infected with Nipah virus (NiV) via aerosol inoculation. Within 15 days of exposure to NiV, signal alterations were observed in the brain in T2-weighted, fluid-attenuated inversion recovery, and diffusion-weighted images, suggestive of infarction, inflammation and edema induced by NiV. The identification of non-invasive imaging biomarkers of acute NiV neurologic disease progression in this animal model could aid in the examination of potential vaccines and therapeutics.

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