Abstract #3196

In vivo longitudinal 1H MRS study of hippocampal, cereberal and striatal metabolic changes in the developing brain using an animal model of Chronic Hepatic Encephalopathy

Dunja Simicic¹, Katarzyna Pierzchala², Veronika Rackayova², Olivier Braissant ³, Stefanita-Octavian Mitrea², Dario Sessa⁴, Valerie McLin⁴, and Cristina Cudalbu Ramona²

¹LIFMET, CIBM, EPFL, Lausanne, Switzerland, ²CIBM, EPFL, Lausanne, Switzerland, ³Neurometabolic Unit, Service of Clinical Chemistry, University Hospital of Lausanne, Lausanne, Switzerland, ⁴Swiss Center for Liver Disease in Children, University Hospitals Geneva, Geneva, Switzerland

Chronic hepatic encephalopathy (CHE) is a severe neuropsychiatric disorder associated with chronic liver disease (CLD). For children, the impairment of neurocognitive functions as a consequence of CLD seems to be irreversible. We aimed to investigate longitudinally, using in-vivo 1H-MRS, differences in metabolic changes between hippocampus, cerebellum and striatum of a developing brain in a rat model of CHE. We showed the most pronounced changes in metabolites in cerebellum, suggesting its increased vulnerability. Further delineation of regional changes in the brain in response to CLD may help elucidate the molecular and regional origins of neuromotor and neurocognitive changes associated with CLD.

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