Altered Functional Topological Properties of Brain Networks in Type-2 Diabetes with and without Mild Cognitive Impairment

This study aims to investigate the functional topological properties in T2DM with and without impairment, and characterize its relationships with clinical measurements. Forty-four T2DM patients were divided into two sub-groups (impaired and normal cognition), together with healthy controls, were imaged at a 3T scanner. We found no significant intergroup difference in global measurements among the three group. However, increased or decreased nodal efficiency was detected in some important brain regions. Altered nodal efficiency in FFG and ITG correlated with glycosylated hemoglobinA1c and neuropsychological assessments. The resting-state functional topological properties research shows potential feasibility in characterizing intrinsic alterations of diabetic encephalopathy.