Perivascular spaces are fluid-filled spaces surrounding blood vessels as they penetrate the brain, forming a brain fluid drainage system that facilitates interstitial fluid exchange and clearance of waste products. Enlargement of perivascular spaces is common in aging, and literature has linked enlarged perivascular spaces (EPVS) to increased risk of stroke, lower cognitive function, and vascular dementia. The links of EPVS burden to age-related neuropathologies have not yet been thoroughly investigated. Therefore, the purpose of this work was to assess the neuropathologic correlates of EPVS by combining ex-vivo MRI and pathology data in a large community cohort of 625 older adults.
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