Alzheimer’s disease (AD) is characterized by reduced cerebral blood flow (CBF) both globally and in AD specific regions, however there is considerable CBF variability even in healthy population. Relative CBF using mean CBF in AD-spared regions as reference removes this variability and can provide higher sensitivity and specificity for regional changes. We compared the effects of using different reference regions in discriminating patients with amnestic mild cognitive impairment (aMCI) and elderly controls using two different arterial spin labeling acquisitions. Putamen and primary motor cortex were most spared in the aMCI cohort and provided best patient-diagnosis when used as reference regions.
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