White matter hyperintensity burden is strongly associated with neuro-inflammation but not with amyloid deposition: a multimodal PET MR study
Hongyu An1, Chunwei Ying1, Yasheng Chen2, Peter Kang2, Jon Christensen1, Qing Wang1, Lisa Cash1, Jin-Moo Lee2, Andria Ford2, and Tammie Benzinger1
1Radiology, Washington University in St. Louis, St. Louis, MO, United States, 2Neurology, Washington University in St. Louis, St. Louis, MO, United States
Selectively elevated PET 11C-PK11195 uptake within white matter demonstrates that neuro-inflammation is an important pathogenic factor in patients with white matter hyperintensities.
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