Action Observation Training (AOT) seems to be a promising tool to improve upper limb function. We applied a novel method of analysis, which allows a time-varying (dynamic) assessment of resting state functional connectivity on two randomized experimental groups of healthy controls and multiple sclerosis (MS) patients and two control groups. Between-group differences and dynamic functional network connectivity (dFNC) changes over-time in each group were evaluated. After a training of 2 weeks, MS groups improved in right upper limb functions and AOT showed a modulation of dFNC of several functional networks in MS patients.
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